多索茶碱和噻托溴铵粉联合治疗对慢性阻塞性肺疾病患者肺功能的效果分析(1)
【摘要】 目的：研究多索茶碱和噻托溴铵粉联合治疗对慢性阻塞性肺疾病患者肺功能的效果，为临床提供指导。方法：选择从2017年7月-2018年7月收治的50例慢性阻塞性肺疾病患者纳入此次研究，按照数字随机方式将其分为试验组与对照组，各25例。对照组接受多索茶碱治疗，试验组接受多索茶碱联合噻托溴铵粉治疗，对比两组患者肺功能各项指标、生活质量各项指标评分。结果：试验组肺功能各项指标[FVC(2.75±0.32)L、FEV1(1.65±0.03)L、FEV1/FVC(60.12±7.12)%]、生活质量各项指标评分[健康状况(41.23±4.89)分、精神健康(54.37±5.12)分、生理功能(72.27±4.76)分]均优于对照组，差异均有统计学意义(P<0.05)。结论：临床治疗慢性阻塞性肺疾病过程中，采用多索茶碱和噻托溴铵粉联合治疗的方式，能够有效改善患者肺功能各项指标，不断提高患者的生活质量，值得临床推广应用。
【关键词】 多索茶碱; 噻托溴铵粉; 联合治疗; 慢性阻塞性肺疾病; 肺功能
doi：10.14033/j.cnki.cfmr.2019.16.050 文献标识码 B 文章编号 1674-6805(2019)16-0-02
【Abstract】 Objective：To study the effect of the combined treatment of Doxofylline and Thiotromonium Bromide Powder on lung function in patients with chronic obstructive pulmonary disease and to provide clinical guidance.Method：A total of 50 patients with chronic obstructive pulmonary disease admitted from July 2017 to July 2018 were included in the study.According to the numerical random division method，they were divided into experimental group and control group respectively，25 cases in each group.The control group was treated with Doxophylline，and the experimental group was treated with Doxophylline combined with Thiotromonium Bromide Powder.Result：The indexes of lung function[FVC (2.75±0.32)L，FEV1 (2.45±0.03)L，FEV1/FVC (60.12±7.12)%]，and the quality of life indicators scores[health status (41.23±4.89)points，mental health (54.37±5.12)points，physiological function (72.27±4.76)points] in the experimental group were better than those in the control group，and there were significant differences between the groups(P<0.05).Conclusion：In the course of clinical treatment of chronic obstructive pulmonary disease，the combination of Doxofylline and Thiotromonium Bromide Powder can effectively improve the pulmonary function of patients and improve the quality of life of patients.It is worth of clinical application.
【Key words】 Doxofylline; Thiotromonium Bromide Powder; Combined treatment; Chronic obstructive pulmonary disease; Pulmonary function
First-author’s address：Jingzhou Thoracic Hospital，Jingzhou 434020，China
慢性阻塞性肺疾病是一種常见、可预防、可治疗的疾病，以不完全可逆的气流受限为特点[1]。由于有害颗粒或气体(主要是吸烟)，肺部产生异常的炎症反应，从而产生气流受限，常常进行性加重。COPD主要影响肺，同时也可以引起显著的全身效应。病因主要包括：吸烟、职业性粉尘和化学物质(烟雾、过敏原、工业废气等)、大气污染(二氧化硫、二氧化氮、氯气等)、感染(细菌、病毒和支原体等)、蛋白酶抗蛋白酶失衡及其他因素(机体内在因素自主神经功能失调营养等突变)，吸烟是最重要的危险因素[2]。临床上以慢性咳嗽、咳痰、进行性加重的呼吸困难为最常见的症状。慢性阻塞性肺疾病常隐匿起病，早期症状不明显，但随着病情发展，患者逐渐出现咳嗽、咳痰、呼吸困难等呼吸道症状，也会伴随乏力、纳差、体重减轻等全身症状，若不及时治疗，很容易引起诸多并发症，严重可威胁患者生命。近年来，随着慢性阻塞性肺疾病的发病率逐渐增加，针对慢性阻塞性肺疾病患者，如何制定更合理有效的治疗方案是临床医生不断探讨和研究的课题[3]。临床上，深入研究并分析多索茶碱联合噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病，对患者肺功能的影响效果具有一定的现实意义。, 百拇医药(张艳霞)
【关键词】 多索茶碱; 噻托溴铵粉; 联合治疗; 慢性阻塞性肺疾病; 肺功能
doi：10.14033/j.cnki.cfmr.2019.16.050 文献标识码 B 文章编号 1674-6805(2019)16-0-02
【Abstract】 Objective：To study the effect of the combined treatment of Doxofylline and Thiotromonium Bromide Powder on lung function in patients with chronic obstructive pulmonary disease and to provide clinical guidance.Method：A total of 50 patients with chronic obstructive pulmonary disease admitted from July 2017 to July 2018 were included in the study.According to the numerical random division method，they were divided into experimental group and control group respectively，25 cases in each group.The control group was treated with Doxophylline，and the experimental group was treated with Doxophylline combined with Thiotromonium Bromide Powder.Result：The indexes of lung function[FVC (2.75±0.32)L，FEV1 (2.45±0.03)L，FEV1/FVC (60.12±7.12)%]，and the quality of life indicators scores[health status (41.23±4.89)points，mental health (54.37±5.12)points，physiological function (72.27±4.76)points] in the experimental group were better than those in the control group，and there were significant differences between the groups(P<0.05).Conclusion：In the course of clinical treatment of chronic obstructive pulmonary disease，the combination of Doxofylline and Thiotromonium Bromide Powder can effectively improve the pulmonary function of patients and improve the quality of life of patients.It is worth of clinical application.
【Key words】 Doxofylline; Thiotromonium Bromide Powder; Combined treatment; Chronic obstructive pulmonary disease; Pulmonary function
First-author’s address：Jingzhou Thoracic Hospital，Jingzhou 434020，China
慢性阻塞性肺疾病是一種常见、可预防、可治疗的疾病，以不完全可逆的气流受限为特点[1]。由于有害颗粒或气体(主要是吸烟)，肺部产生异常的炎症反应，从而产生气流受限，常常进行性加重。COPD主要影响肺，同时也可以引起显著的全身效应。病因主要包括：吸烟、职业性粉尘和化学物质(烟雾、过敏原、工业废气等)、大气污染(二氧化硫、二氧化氮、氯气等)、感染(细菌、病毒和支原体等)、蛋白酶抗蛋白酶失衡及其他因素(机体内在因素自主神经功能失调营养等突变)，吸烟是最重要的危险因素[2]。临床上以慢性咳嗽、咳痰、进行性加重的呼吸困难为最常见的症状。慢性阻塞性肺疾病常隐匿起病，早期症状不明显，但随着病情发展，患者逐渐出现咳嗽、咳痰、呼吸困难等呼吸道症状，也会伴随乏力、纳差、体重减轻等全身症状，若不及时治疗，很容易引起诸多并发症，严重可威胁患者生命。近年来，随着慢性阻塞性肺疾病的发病率逐渐增加，针对慢性阻塞性肺疾病患者，如何制定更合理有效的治疗方案是临床医生不断探讨和研究的课题[3]。临床上，深入研究并分析多索茶碱联合噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病，对患者肺功能的影响效果具有一定的现实意义。, 百拇医药(张艳霞)